Eligibility

Investigators must have PI status and a current NIH funded grant and conducting research at a U.S. academic institution.

Call for Applications

Please contact the CSGE to discuss your project and to obtain an application form. (see pdf for application process)

All vectors proposed for use (viral or nonviral) must be provided by the investigator and at the quality required, with a documented Certificate of Analysis ensuring appropriate screens and sterility. Additional aliquots must be provided for Center testing prior to use. All animals are extensively screened and selected based on study requirements.

Examples of collaborative services offered:

• Study development and design
• Extensively screened nonhuman primates across age groups (fetal to adult) based on study needs
• Systemic and organ-targeting approaches including in utero (range of routes targeting specific cells and organ systems) and neonatal/infant administration (e.g., intrathecal, intrarenal, intrahepatic, systemic).
• Use of viral or nonviral vectors (must be of the quality required)
• In vivo imaging (e.g., ultrasound, optical imaging, PET/CT, inflation CT, total-body PET)
• Physiologic assessments
• Immunogenicity and inflammation evaluations
• Molecular and cellular assays
• Biodistribution
• On- and off-target editing
• Safety and efficiency

Examples of assays include:

• Complete blood counts (CBCs) and clinical chemistry panels
• Flow Cytometry, Cell Sorting, Immunoselection
• Immune-based assays including antibody ELISAs
• Hematopoietic assays (e.g., CFUs)
• DNA/RNA isolation and quantitative RT-PCR and ddPCR
• Immunohistochemistry, RNAscope